How many questions does AceMRCOG have?

AceMRCOG has 1,750 expertly curated MRCOG Part 1 SBA questions across all 14 subjects including Physiology, Pharmacology, Microbiology, Genetics, Pathology, Anatomy, Statistics, Immunology, Biochemistry, Endocrinology, Biophysics, Neonatology, Clinical Management and Embryology.

Yes. AceMRCOG offers a free plan with 50 questions — no credit card required. Paid plans unlock all 1,750 questions, timed mock tests, detailed explanations and performance analytics.

Does AceMRCOG have mock tests?

Yes. Paid plans include full timed mock tests that simulate the real MRCOG Part 1 exam format. Each mock has 100 questions with a 90-minute timer, matching the actual exam conditions.

What is the MRCOG Part 1 pass rate?

The MRCOG Part 1 first-attempt pass rate is approximately 40-50%. Candidates who practice at least 1,500 questions and complete multiple timed mock tests significantly improve their chances of passing on the first attempt.

How long should I study for MRCOG Part 1?

Most successful candidates study for 3-6 months. If working clinically, 3 months with 1.5-2 hours of daily structured study and daily question practice is achievable. The key is consistent question practice — at least 30 questions per day.

What subjects are tested in MRCOG Part 1?

MRCOG Part 1 tests 14 subjects: Physiology, Pharmacology, Microbiology, Genetics, Pathology, Anatomy, Statistics & Epidemiology, Immunology, Biochemistry, Endocrinology, Biophysics, Neonatology, Clinical Management and Embryology.

When is the MRCOG Part 1 exam held?

The MRCOG Part 1 exam is held twice a year — typically in March and September. Exact dates are published by the RCOG on their official website. Registration usually opens 3-4 months before the exam date.

MRCOG Part 1 Subject Guide

MRCOG Part 1: Biochemistry

~70 questionsMedium priority

Biochemistry covers the molecular and metabolic basis of physiology relevant to O&G. Approximately 70 questions, with particular emphasis on enzyme kinetics, metabolic pathways, steroid hormone biochemistry and cell signalling. This subject overlaps significantly with Physiology and Endocrinology.

Topics Covered

Enzymes & Metabolism

›Enzyme kinetics — Km, Vmax, Michaelis-Menten curve, competitive vs non-competitive inhibition
›Glycolysis, TCA cycle, oxidative phosphorylation
›Fatty acid oxidation and synthesis
›Amino acid metabolism and urea cycle
›Glycogen metabolism — glycogenolysis, glycogenesis

Steroid Hormone Biochemistry

›Steroidogenesis — cholesterol → pregnenolone → progesterone → oestrogen pathway
›Enzymes in steroidogenesis: P450 aromatase (CYP19), 17α-hydroxylase, 3β-HSD
›Adrenal steroidogenesis — cortisol, aldosterone, DHEA
›Congenital adrenal hyperplasia — 21-hydroxylase deficiency (most common)

Cell Signalling

›G-protein coupled receptors — cAMP/PKA, IP3/DAG pathways
›Receptor tyrosine kinases — insulin receptor, growth factor signalling
›Nuclear receptors — steroid hormones, thyroid hormone (direct DNA binding)
›Second messengers — cAMP, cGMP, calcium/calmodulin

Molecular Biology

›DNA replication — DNA polymerase, leading and lagging strands
›Transcription and translation — promoters, RNA polymerase, ribosomes
›Post-translational modification — phosphorylation, glycosylation, ubiquitination
›Protein structure — primary, secondary, tertiary, quaternary

Exam Tips for Biochemistry

Steroidogenesis pathway is highly tested — know the enzymes at each step and what deficiency causes what syndrome.

21-hydroxylase deficiency is the most tested CAH: salt-wasting, virilisation, elevated 17-hydroxyprogesterone.

Enzyme kinetics: Km is the substrate concentration at half Vmax — lower Km means higher affinity.

Know the difference between nuclear receptors (steroid hormones — act directly on DNA) vs cell surface receptors.

Michaelis-Menten vs Lineweaver-Burk plots — be able to read both and identify inhibitor type.

Recommended Book

✓ Harper's Illustrated Biochemistry (relevant chapters) or Lippincott's Biochemistry.

Practice Biochemistry questions now

AceMRCOG has 70 Biochemistry SBA questions with detailed explanations. Start with 50 questions free — no credit card needed.

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Related Subjects

Physiology

~139 questions

Endocrinology

~55 questions

Genetics

~135 questions

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