MRCOG Part 1: Microbiology
Microbiology has the highest question count of any MRCOG Part 1 subject, with approximately 165 questions. It covers bacteria, viruses, fungi and parasites relevant to obstetrics and gynaecology — with particular emphasis on sexually transmitted infections, infections in pregnancy and antimicrobial agents.
Topics Covered
Sexually Transmitted Infections
- ›Chlamydia trachomatis — biology, clinical features, diagnosis (NAAT), treatment
- ›Neisseria gonorrhoeae — gram-negative diplococcus, beta-lactamase resistance
- ›Treponema pallidum (syphilis) — stages, congenital syphilis, serology (TPHA, VDRL, FTA)
- ›Herpes simplex virus (HSV-1 and HSV-2) — primary vs recurrent, neonatal herpes risk
- ›Human papillomavirus (HPV) — types 6, 11, 16, 18; cervical dysplasia; vaccination
- ›Trichomonas vaginalis — flagellated protozoan, metronidazole treatment
- ›HIV in pregnancy — PMTCT, timing of transmission, antiretrovirals
Bacterial Infections in Pregnancy
- ›Group B Streptococcus (GBS) — neonatal sepsis, intrapartum prophylaxis
- ›Listeria monocytogenes — gram-positive, unpasteurised dairy, meningitis in neonates
- ›E. coli — UTI, neonatal meningitis (K1 antigen)
- ›Bacterial vaginosis — Gardnerella, Clue cells, Amsel criteria, preterm birth risk
- ›Chorioamnionitis — ascending infection, organisms, management
Viral Infections in Pregnancy
- ›Rubella — MMR vaccine, 12-week booking screen, congenital rubella syndrome
- ›CMV — most common congenital infection, effects on neonate
- ›Varicella zoster — chickenpox in pregnancy risks, neonatal varicella, VZIG
- ›Parvovirus B19 — hydrops fetalis, slapped cheek disease
- ›Hepatitis B — surface antigen, transmission, neonatal immunisation
- ›Hepatitis C — vertical transmission rate, no vaccine
Microbiology Principles
- ›Gram staining — gram-positive vs gram-negative organisms and cell wall differences
- ›Bacterial structure — endotoxin (LPS) in gram-negatives, peptidoglycan
- ›Mechanisms of antibiotic resistance — beta-lactamase, MRSA, ESBL
- ›Bacteraemia, sepsis and SIRS criteria
- ›Prions, viroids and atypical pathogens (Chlamydia, Mycoplasma, Rickettsia)
Exam Tips for Microbiology
Know Gram stain classification for every major pathogen — this is tested directly and determines treatment.
Congenital infection effects (TORCH — Toxoplasma, Rubella, CMV, HSV) are high-yield: know the specific neonatal consequences.
Syphilis serology is complex: understand VDRL (non-specific, affected by pregnancy), TPHA (specific treponemal test).
Group B Strep is a recurring question: know risk factors for neonatal disease and intrapartum antibiotic prophylaxis criteria.
HPV types must be memorised: 6 & 11 = genital warts; 16 & 18 = cervical cancer (high-risk).
Recommended Book
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