MRCOG Part 1 Subject Guide

MRCOG Part 1: Microbiology

~165 questionsHigh priority

Microbiology has the highest question count of any MRCOG Part 1 subject, with approximately 165 questions. It covers bacteria, viruses, fungi and parasites relevant to obstetrics and gynaecology — with particular emphasis on sexually transmitted infections, infections in pregnancy and antimicrobial agents.

Topics Covered

Sexually Transmitted Infections

  • Chlamydia trachomatis — biology, clinical features, diagnosis (NAAT), treatment
  • Neisseria gonorrhoeae — gram-negative diplococcus, beta-lactamase resistance
  • Treponema pallidum (syphilis) — stages, congenital syphilis, serology (TPHA, VDRL, FTA)
  • Herpes simplex virus (HSV-1 and HSV-2) — primary vs recurrent, neonatal herpes risk
  • Human papillomavirus (HPV) — types 6, 11, 16, 18; cervical dysplasia; vaccination
  • Trichomonas vaginalis — flagellated protozoan, metronidazole treatment
  • HIV in pregnancy — PMTCT, timing of transmission, antiretrovirals

Bacterial Infections in Pregnancy

  • Group B Streptococcus (GBS) — neonatal sepsis, intrapartum prophylaxis
  • Listeria monocytogenes — gram-positive, unpasteurised dairy, meningitis in neonates
  • E. coli — UTI, neonatal meningitis (K1 antigen)
  • Bacterial vaginosis — Gardnerella, Clue cells, Amsel criteria, preterm birth risk
  • Chorioamnionitis — ascending infection, organisms, management

Viral Infections in Pregnancy

  • Rubella — MMR vaccine, 12-week booking screen, congenital rubella syndrome
  • CMV — most common congenital infection, effects on neonate
  • Varicella zoster — chickenpox in pregnancy risks, neonatal varicella, VZIG
  • Parvovirus B19 — hydrops fetalis, slapped cheek disease
  • Hepatitis B — surface antigen, transmission, neonatal immunisation
  • Hepatitis C — vertical transmission rate, no vaccine

Microbiology Principles

  • Gram staining — gram-positive vs gram-negative organisms and cell wall differences
  • Bacterial structure — endotoxin (LPS) in gram-negatives, peptidoglycan
  • Mechanisms of antibiotic resistance — beta-lactamase, MRSA, ESBL
  • Bacteraemia, sepsis and SIRS criteria
  • Prions, viroids and atypical pathogens (Chlamydia, Mycoplasma, Rickettsia)

Exam Tips for Microbiology

1

Know Gram stain classification for every major pathogen — this is tested directly and determines treatment.

2

Congenital infection effects (TORCH — Toxoplasma, Rubella, CMV, HSV) are high-yield: know the specific neonatal consequences.

3

Syphilis serology is complex: understand VDRL (non-specific, affected by pregnancy), TPHA (specific treponemal test).

4

Group B Strep is a recurring question: know risk factors for neonatal disease and intrapartum antibiotic prophylaxis criteria.

5

HPV types must be memorised: 6 & 11 = genital warts; 16 & 18 = cervical cancer (high-risk).

Recommended Book

Medical Microbiology by Murray, Rosenthal & Pfaller (9th Edition) — use selectively, focus on STI and obstetric chapters.

Practice Microbiology questions now

AceMRCOG has 165 Microbiology SBA questions with detailed explanations. Start with 50 questions free — no credit card needed.

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