How many questions does AceMRCOG have?

AceMRCOG has 1,750 expertly curated MRCOG Part 1 SBA questions across all 14 subjects including Physiology, Pharmacology, Microbiology, Genetics, Pathology, Anatomy, Statistics, Immunology, Biochemistry, Endocrinology, Biophysics, Neonatology, Clinical Management and Embryology.

Yes. AceMRCOG offers a free plan with 50 questions — no credit card required. Paid plans unlock all 1,750 questions, timed mock tests, detailed explanations and performance analytics.

Does AceMRCOG have mock tests?

Yes. Paid plans include full timed mock tests that simulate the real MRCOG Part 1 exam format. Each mock has 100 questions with a 90-minute timer, matching the actual exam conditions.

What is the MRCOG Part 1 pass rate?

The MRCOG Part 1 first-attempt pass rate is approximately 40-50%. Candidates who practice at least 1,500 questions and complete multiple timed mock tests significantly improve their chances of passing on the first attempt.

How long should I study for MRCOG Part 1?

Most successful candidates study for 3-6 months. If working clinically, 3 months with 1.5-2 hours of daily structured study and daily question practice is achievable. The key is consistent question practice — at least 30 questions per day.

What subjects are tested in MRCOG Part 1?

MRCOG Part 1 tests 14 subjects: Physiology, Pharmacology, Microbiology, Genetics, Pathology, Anatomy, Statistics & Epidemiology, Immunology, Biochemistry, Endocrinology, Biophysics, Neonatology, Clinical Management and Embryology.

When is the MRCOG Part 1 exam held?

The MRCOG Part 1 exam is held twice a year — typically in March and September. Exact dates are published by the RCOG on their official website. Registration usually opens 3-4 months before the exam date.

MRCOG Part 1 Subject Guide

MRCOG Part 1: Immunology

~60 questionsMedium priority

Immunology covers the mechanisms of immune defence, tolerance and disease. Approximately 60 questions, with particular focus on immune tolerance in pregnancy (a fundamental O&G concept), autoimmune conditions in pregnancy and transplant immunology.

Topics Covered

Innate Immunity

›Physical barriers — skin, mucosa, mucociliary clearance
›Phagocytes — neutrophils, macrophages, dendritic cells
›Natural killer (NK) cells — role in early pregnancy and uterine decidua
›Complement system — classical, lectin, alternative pathways; C3, C5, MAC
›Pattern recognition — Toll-like receptors, PAMPs and DAMPs

Adaptive Immunity

›T lymphocytes — CD4+ helper (Th1, Th2, Th17, Treg), CD8+ cytotoxic
›B lymphocytes — antibody production, class switching
›MHC (HLA) — Class I (all nucleated cells, CD8+), Class II (APCs, CD4+)
›Immunoglobulin classes — IgG (crosses placenta), IgA (secretory), IgM (first response)
›Primary vs secondary immune response — memory cells, affinity maturation

Immunology of Pregnancy

›Maternal tolerance to fetal allograft — why the fetus is not rejected
›HLA-G expression on trophoblast — protects from NK cell attack
›Th1/Th2 shift in pregnancy — Th2 predominance promotes tolerance
›Regulatory T cells (Tregs) — expanded in pregnancy, promote tolerance
›Anti-D antibodies and haemolytic disease of the newborn — Rh incompatibility

Autoimmunity & Allergy

›Antiphospholipid syndrome — anti-cardiolipin and anti-beta2-glycoprotein I antibodies, recurrent miscarriage
›Systemic lupus erythematosus in pregnancy — lupus flare, neonatal lupus
›Type I hypersensitivity (anaphylaxis) — IgE, mast cells, histamine
›Type II (cytotoxic), III (immune complex), IV (delayed, T-cell mediated) hypersensitivity

Exam Tips for Immunology

Maternal tolerance to the fetal semi-allograft is a classic question — know HLA-G, Tregs and Th2 shift.

Anti-D: know when to give (all Rh-negative women at risk of sensitisation), dose (500 IU at 28 weeks; 250 IU for events <20 weeks).

Immunoglobulin classes: IgG is the only one that crosses the placenta (active transport via FcRn receptor).

APS criteria: need both clinical (thrombosis or pregnancy loss) AND lab criteria (antibodies on two occasions ≥12 weeks apart).

MHC Class I vs II: Class I presents endogenous antigens to CD8+ T cells; Class II presents exogenous antigens to CD4+ T cells.

Recommended Book

✓ Roitt's Essential Immunology — covers all MRCOG immunology in a readable format.

Practice Immunology questions now

AceMRCOG has 60 Immunology SBA questions with detailed explanations. Start with 50 questions free — no credit card needed.

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Related Subjects

Microbiology

~165 questions

Pathology

~100 questions

Genetics

~135 questions

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